第二章蛋白质的结构和功能

• 【简答题】You can answer the question either in Chinese or EnglishA 15-year-old African-Am…
• A 55-year-old British teacher presents with weight loss, weakness, muscle atrophy, and dec…
• The oxygen carrier of muscle is the globular protein myoglobin. Which of the following ami…
• A 6-year-old African American girl with speech delay is found to have a large, abnormal pe…
• Select the one of the following statements that is NOT CORRECT : A、Ion-exchange chromato…
• Select the one of the following statements that is NOT CORRECT : A、Protein folding is …
• Select the one of the following statements that is NOT CORRECT : A、Changes in configurati…
•  Select the one of the following statements that is NOT CORRECT : A、The Bohr effect refe…
• Consider the amino acid shown below. The configuration about which atom will determine whe…
• Which of the following amino acids are belonged to the acidic amino acids? A、Phe Tyr B、M…
• The covalent bond formed between the carboxyl group of one amino acid and the amino group …
• A part of protein sequence that can form a compact three-dimensional structure and often c…
• Proteins are large biological molecules consist of which of the following amino acids? A…
• Which of the following amino acids are belonged to the basic amino acids? A、Phe Tyr B、M…
• Consider the following structure: This structure is best described as which of the follow…
• A 56-year-old pathologist was taken to his family doctor by his son for he was showing moo…
• When using Biuret's test, which macromolecule will produce a positive reaction (colour ch…
• A single polypeptide that assembles with other polypeptides to form a protein complex is b…
• How many amino acids are involved in making proteins in humans? A、5 B、20 C、35 D、64
• Amino acids join up into a large chain (polymer) to create what biological molecule(s)? A…

第十五章RNA的生物合成

• Lipoproteins transport lipids from intestine and liver where they are absorbed and metabol…
• If the DNA strand shown below is used as a template for RNA polymerase, what would be the …
• All of the following are true of RNA polymerase except: A、Catalyze the synsthesi…
• A careful analysis of cellular components discovers short-lived RNA species in …
• A patient suffering from chills, vomiting, and cramping was rushed to the emergency depart…
• An intestinal cell line was being studied for its ability to produce lipid-containing part…
• A man with a bacterial infection was prescribed rifampin to resolve the infection. Rifampi…
• Small snRNPs are involved in: A、Translation B、Transcription C、mRNA processing D、Ca…
• All of the following are true of RNA polymerase except: A、It binds to most regio…
• The site to which RNA polymerase binds on the DNA template prior to the initiation of tran…
• case study A 25-year-old Mediterranean female presents to her obstetrician at 12-weeks ges…

第十四章DNA的生物合成

• why mammalian genomes are 100 times the size of bacterial genomes yet are replicated in ju…
• A 2-year-old child presents with poor weight gain, sparse hair, unusual face with sunken e…
• Part of the triplet genetic code involving mRNA codon triplets that start with U is shown …
• Replication of DNA starts with the unwinding of the entire DNA molecule. Each original str…
• DNA replication results in: A、Protein production B、Two new daughter strands C、Heavy …
• DNA replication is semiconservative. Why do you think this is true? A、Requires …
• Why does lagging strand synthesis consist of discontinuous Okazaki fragments? A、…
• Single-stranded binding proteins (SSB) bind to the outer backbone of DNA during replicatio…
• Telomerase contains a ribozyme. A、Telomerase contains a ribozyme. B、Telomerase adds a…
• DNA replication is not perfect; a mistake is made for every 104 to 105 nucleotides added. …
• case study A 2-year-old Scottish-American girl presents with deeply pigmented and scarred …

第十二章与肝胆生化

• 发生在肝生物转化第二阶段 A、葡糖醛酸结合反应 B、氧化反应 C、还原反应 D、水解反应 E、脂化反…
• 胆汁中含量最多的有机成分是 A、胆色素 B、胆汁酸 C、胆固醇 D、磷脂 E、黏蛋白…
• 属于次级非结合胆汁酸的是 A、甘氨胆酸 B、牛磺胆酸 C、鹅脱氧胆酸 D、牛磺鹅脱氧胆酸 E、石胆酸…
• 下列关于游离胆红素的叙述，正确的是 A、胆红素与葡糖醛酸结合 B、水溶性较大 C、易透过生物膜 D、…
• 下列哪种物质是结合胆红素？ A、胆红素清蛋白 B、胆红素－Y蛋白 C、胆红素乙蛋白 D、葡糖醛酸胆红素 …
• 完全性梗阻性黄疸时，正确的是 A、尿胆原（－）尿胆红素（－） B、尿胆原（＋）尿胆红素（－） C、尿胆原（－）尿胆红素（＋） D、尿胆原…
• 胆红素生成的限速酶是: A、单胺氧化酶 B、血红素加氧酶 C、胆红素加氧酶 D、胆红素氧化酶 E、胆…
• 下列哪一物质为初级结合胆汁酸？ A、石胆酸 B、牛磺胆酸 C、脱氧胆酸 D、鹅脱氧胆酸 E、甘氨石胆酸…
• 肝穿刺活检发现肝大．肝细胞内糖原颗粒累积，颗粒糖原分支处仍然保留单个葡萄糖残基，可能功能有缺陷的…
• Select the one of the following statements that is NOT CORRECT : A、The Bohr effect refers…

第十一章血液生化

• 以醋酸纤维素薄膜作支持物进行血清蛋白质电泳的缓冲液常用的pH为 A、3.5 B、5.5 C、6.5 D、7.5 E…
• 在血浆蛋白电泳中，泳动最慢的蛋白质是 A、清蛋白 B、a1－球蛋白 C、a2－球蛋白 D、B－球蛋白 E、－球蛋白…
• 血浆蛋白质中含量最多的是 A、清蛋白 B、α1－球蛋白 C、α2－球蛋白 D、β－球蛋白 E、γ球蛋白…
• 具有氧化酶活性的是 A、免疫球蛋白 B、肌红蛋白 C、脂蛋白 D、铜蓝蛋白 E、清（白）蛋白…
• 转运游离脂肪酸的是 A、免疫球蛋白 B、肌红蛋白 C、脂蛋白 D、铜蓝蛋白 E、清（白）蛋白…
• 合成血红素的原料是 A、CoA、甘氨酸、Fe2+ B、琥珀酰CoA、甘氨酸、Fe2+ C、乙酰CoA、组氨酸、Fe2…
• 下列关于血红蛋白合成的叙述，正确的是 A、以甘氨酸、天冬氨酸为原料 B、只有成熟红细胞才能进行 C…
• 属于血红蛋白直接分解产物的物质是 A、胆红素 B、血栓素 C、细胞色素c D、血红素 E、胆素原…
• 下列关于血红蛋白的叙述,错误的是 A、是含有铁卟啉辅基的蛋白质 B、存在紧张态和松弛态两种构象 …
• 成熟红细胞不具有的代谢途径是： A、糖酵解 B、磷酸戊糖途径 C、三羧酸循环 D、2,3-BPG支路 E、氧…

第十章核苷酸代谢

• 男，51岁，近3年来出现关节炎症状和尿路结石，进食肉类食物时，病情加重。该患者发生的疾病涉及代谢途径…
• 与体内尿酸堆积相关的酶是 A、酰胺转移酶 B、四氢叶酸还原酶 C、转甲酰基酶 D、黄嘌呤氧化酶 E、…
• 体内嘌呤核苷酸的分解代谢终产物是 A、尿素 B、NH C、β－丙氨酸 D、β－氨基异丁酸 E、尿酸…
• 与抗代谢药5－FU化学结构相似的物质是 A、腺嘌 B、鸟嘌呤 C、胸腺嘧啶 D、尿嘧啶 E、胞嘧啶…
• 下列物质含量异常可作为痛风诊断指征的是 A、嘧啶 B、嘌呤 C、β－氨基异丁酸 D、尿酸 E、β－丙氨酸…
• 嘌呤从头合成的氨基酸有 A、鸟氨酸 B、谷氨酸 C、天冬酰胺 D、天冬氨酸 E、丙氨酸…
• 合成嘌呤、嘧啶的共同原料是 A、甘氨酸 B、天冬酰胺 C、谷氨酸 D、天冬氨酸 E、氨基甲酰磷酸…
• 在体内能分解生成β－氨基异丁酸的是 A、AMP B、GMP C、CMP D、UMP E、TMP
• 氮杂丝氨酸干扰核苷酸合成是因为它的结构类似于 A、丝氨酸 B、甘氨酸 C、天冬氨酸 D、天冬酰胺 E…
• 干扰dUMP转变生成dTMP的是 A、6巯基嘌呤 B、甲氨蝶呤 C、链霉素 D、别嘌呤醇 E、阿糖胞苷…

第九章氨基酸代谢

• In the presence of hyperammonia, production of which of the following amino ac…
• The primary manner for the deamination of amino acids in muscle involves. A、p…
• The major fate of ammonia is (    ) in the body. A、to synthesize nonessenti…
• Which of the following are the nitrogen source of urea ?  A、carbomoyl phosphate and aspa…
• Which of the following amino acids can be converted into taurine in the body?…
• The compound which does not belong to one carbon unit as follow is.  A、-CH3 B、=CH2 C、=…
• Which of the following is the carrier of one carbon unit ?  A、biotin B、SAM …
• The most important role of S-adenosyl methionine (SAM) is. A、to provide methionine B、to …
• Which of the following state is nitrogen equilibrium? A、advanced cancer patient B、pregna…
• Which of the following amino acid can not produce one carbon unit?    A、Serine B、Valin…
• The transportation form of ammonia in blood is  A、Glutamate  B、Tyrosine  C、Gl…
• Which of the following state is positive nitrogen balance?  A、advanced cancer B、pregnan…
• Which of the following is not produced by Tyr? A、norepinephrine B、epinephrine C…
• Which of the following is the main deamination style in the body? A、oxidation …
• Which of the following amino acid can produce PAPS?  A、taurine B、methionine C、…
• Which of the following is the process that transport ammonia from muscle to l…
• Which one of the following amino acids is essential in the human diet?  A、Serine B、Lysi…
• When compared to his state after an overnight fast, a person who fasts for 1 week will hav…
• Which of the following is the direct donor of CH3?  A、N5-CH3-FH4 B、SAM C、N5,N10- CH2-F…
• Mr Smith had been prescribed a drug to treat his depression. One of the effects of the dru…

第八章脂类代谢

• A 48-year-old male presents to the clinic because of concerns about heart disease. He repo…
• Which one of the following statements about the absorption of lipids from the intestine is…
• The rate-limting enzyme in the β-oxidation of fatty acid is A、acyl CoA syntheta…
• In liver, large numbers of acetyl CoA derived from fat mobilization convert ma…
• Rate-limiting enzyme in the synthesis of ketone bodies is A、thiolase B、HMG-CoA s…
• The compound which can not be oxidized into CO2 and H2O in vivo is A、acetoac…
• The activated choline required for the lecithin biosynthesis is  A、ADP- choline B、CDP- …
• Which is the following can transfer acetyl group from mitochondria to cytoplasm  A、Acety…
• After they are produced from acetyl-CoA in the liver, ketone bodies are mainly used for wh…
• The class of drugs called statins have proved very effective against hypercholesterolemia,…
• Which one of the following statements concerning chylomicrons is CORRECT? A、Chylomicrons …
• The subcellular site of the breakdown of long chain fatty acids to acetyl-CoA via -oxidati…
• You are examining a patient who exhibits fasting hypoglycemia and need to decide between a…
• A patient presents in your office with very high levels of serum cholesterol. After a seri…
• Under condition of starvation, the major fuel for the brain is A、blood glucose B、fatty a…
• A patient presents in your office with very high levels of serum cholesterol. He states th…
• Synthesis of fatty acids occurs in the cytoplasm, and is catalyzed by fatty acid synthase.…
• All of the following are derived from cholesterol except: A、Bile salts B、Progesterone C…
• In humans, obesity is not caused by leptin levels, but by malfunctioning signal mechanisms…
• A 7-year-old girl has 1 1-month history of foul-smelling diarrhea. Upon further inquiry, t…
• A 19-year-old man complains of “brown urine” and pain in the muscles of his arms and leg…
• A newborn infant had trouble breathing at birth. The infant was 3 months premature. The ph…

第七章生物氧化

第六章糖代谢

• Case file study（You can answer the question either in Chinese or English) A 50-year-old His…
• Which one of the following statements concerning glycolysis is correct?  A、The conversio…
• Which one of the following is a condition decreased the oxidation of acetyl CoA by the cit…
• The synthesis of glucose from pyruvate by gluconeogenesis: A、occurs exclusively in the cy…
• A two year-old boy was brought into the emergency room, suffering from severe fasting hypo…
• Epinephrine and glucagon have which one of the following effects on glycogen metabolism in…
• Most of the reducing equivalents utilized for synthesis of fatty acids can be generated fr…
• Which coenzyme in pyruvate dehydrogenase complex serves as the final hydrogens acceptor? …
• The degradation of glycogen normally produces  A、more glucose than glucose l-phosphate B…
• In which compartment of the cell does glycolysis occur?  A、Mitochondrion B、Nucleus C、S…
• How many net molecules of ATP are generated in the conversion of glucose to pyruvate? A、0…
• Which of the following statements about glycolysis is TRUE? A、Glucokinase catalyzes the c…
• NADH is required for the one-step reaction by which pyruvate is converted to  A、oxaloace…
• Which of the following glycolytic enzymes is used in gluconeogenesis?   A、Glucokinase B…
• An infant with an enlarged liver has a glucose 6-phosphatase deficiency. This infant  A、…
• The pentose phosphate pathway generates each of the following products EXCEPT  A、NADPH, …
• The unique pathway for mature red blood cells to obtain ATP is A、pentose phosphate pathwa…
• Which enzyme is the key enzyme in glycogenolysis (glycogen degradation) ?  A、Phosphoryla…
• Which of the following metabolic pathway take place in the mitochondira? A、A.glycolytic p…
• The principl function of the TCA cycle is to   A、generate CO2 B、transfer electrons from…
• The compound which can not be converted into glucose is in animals. A、lactate B、pyruvate…

第五章糖复合物

• Select the one FALSE statement: A、Marfan syndrome is due to mutations in the gene encodin…
• Regarding the ABO blood group substances, select the one FALSE statement: A、They can be e…
• A male infant is failing to thrive and, on examination, is noted to have hepatomegaly and …
• All of the following sugars are found in glycoproteins EXCEPT: A、Fructose B、Fucose C、Ga…
• Select the one FALSE statement: A、Mucins contain predominantly O-linked glycans. B、O-lin…
• 以下说法错误的是： A、糖蛋白和蛋白聚糖都是由糖与蛋白质两部分由共价键连接组成。 B、组成蛋白聚…
• 鞘糖脂的分子组成包括： A、甘油 B、鞘氨醇 C、磷酸 D、糖链 E、脂肪酸…
• 体内重要的糖胺聚糖有： A、硫酸软骨素 B、硫酸角质素 C、肝素 D、硫酸皮肤素 E、透明质酸…
• 以下说法正确的是： A、糖蛋白和蛋白聚糖都是由糖与蛋白质两部分由共价键连接组成。 B、组成蛋白聚…
• 在N-连接糖蛋白中，N-糖链主要存在以下哪几种亚型？ A、高甘露糖亚型 B、低甘露糖亚型 C、复杂亚型 D…

第四章酶与辅酶

• A 47-year-old female is brought to the emergency department with complaints of malaise, na…
• A 50-year-old man has been trying to lose weight, but he enjoyed eating so much that he fo…
• Routine newborn screening identified a child with elevated levels of α-ketoacids of the b…
• deficiency in which of the following vitamins will lead to a functional folate deficiency?…
• 关于酶抑制剂的叙述正确的是： A、酶的抑制剂中是酶的变性剂 B、酶的抑制剂只与活性中心上的基团结…
• 泛酸是下列哪种生化反应中酶所需辅酶成分? A、脱羧作用 B、脱氢作用 C、还原作用 D、乙酰化作用 …
• A newborn has milky white skin, white hair, and red-appearing eye color (see the figure be…
• In a laboratory study, volunteers were made experimentally vitamin B6 deficient, and much …
• 为了防止酶失活，最好将酶制剂存放于以下什么条件 A、0℃避光 B、室温曝光 C、室温避光 D、最适温…
• 乳酸脱氢酶属于： A、转移酶类 B、水解酶类 C、氧化还原酶类 D、异构酶类 E、裂解酶类…
•  在离体线粒体实验中测得一底物的P/O比值是1.8，该底物脱下的氢最有可能在下列哪一部位进入呼吸链…
• 酶原激活的生理意义是： A、加速代谢 B、恢复酶活性 C、促进生长 D、避免自身损伤 E、保护酶的活性…
• 下列关于Km值的描述哪一项是错误的？ A、是酶的特征性常数 B、近似表示酶催化底物转变为产物的能力…
• 酶原缺乏活性的主要原因是： A、肽链合成时缺少某些肽段 B、活性中心未形成 C、未结合辅酶 D、缺乏…
• 下列有关温度对酶反应速度影响的叙述中，错误的是： A、温度对酶促反应速度的影响不仅包括升高温度使…
• 关于酶的激活剂的叙述错误的是： A、激活剂可能是无机离子，中等大小有机分子和具蛋白质性质的大分子…

第三章核酸的结构与功能

• A 21-year-old female presents to the physician’s office with complaints of very painful v…
• The sequence of part of a DNA strand is the following: -ATTCGATTGCCCACGT-. When this stran…
• Which of these three-letter codes is correct regarding the amino acid isoleucine? A、Ile B…
• The description of the secondary structure of DNA double helix are correct, EXCEPT A、Two …
• The correct description about Tm is  A、The temperature at which half of the maxim…
• If the coden of mRNA is ACG, then the anticoden of tRNA is A、UGC B、TGC C、GCA D、CGU E、…
• The linkage between nucleotides is  A、2’,-3’ phosphodiester bond; B、3’,-5’ phosphod…
• The template strand of DNA is 5’-ATTCAG-3 ’ , its transcript is A、5’ -GACTTA-3’ B、5…
• While studying the structure of a small gene that was recently sequenced durin…
• All of the following are true of the differences between DNA and RNA except: A、RNA utiliz…
• DNA secondary structure is a right-handed double helix with a sugar phosphate backbone on …
• The hyperchromic effect refers to the increase in the UV absorption of DNA. This is a resu…
• RNA also has some structure. These include all of the following except: A、Hairpin turns B…
• In order to package the 3x109 nucleotides of DNA into the nucleus, the DNA is wound around…
• Small snRNPs are involved in: A、Translation B、mRNA processing C、Transcription D、Cataly…
• The core proteins in nucleosome are  A、H2A, H2B, H3, H4. B、H1A, H1B, H3, H4. C、H1A, H2…

第十六章蛋白质的翻译

• 关于编码链，正确的说法是： A、可以作为模板 B、与mRNA碱基序列一致 C、与mRNA的序列互补 D、编码链…
• 翻译过程的错误叙述是： A、以mRNA为模板 B、需要启动子起始 C、需要氨酰tRNA D、在核糖体上进行 E…
• 原核生物的起始密码翻译为： A、甲硫氨酸 B、甘氨酸 C、天冬酰胺 D、甲酰甲硫氨酸 E、天冬氨酸…
• 在翻译过程中，正确的说法有： A、翻译终止后，核蛋白体的大小亚基是不分开的 B、在起始阶段，P位是一直…
• 在原核生物起始密码子上游协助翻译起始的特殊结构称为: A、帽结构 B、冈崎片段 C、SD序列 D、增…
• 催化氨基酸与tRNA结合的酶是: A、氨基转移酶 B、氨基酰tRNA合成酶 C、氨基酸活化酶 D、tRNA生物…
• mRNA上决定翻译终止的信号是: A、终止子 B、终止因子 C、终止氨基酸 D、终止密码子 E、终止盒…
• 真核生物的起始密码翻译为： A、甲硫氨酸 B、甘氨酸 C、天冬酰胺 D、甲酰甲硫氨酸 E、天冬氨酸…
• 原核生物的起始密码只能编码： A、亮氨酸 B、甘氨酸 C、蛋氨酸 D、甲酰蛋氨酸 E、天冬氨酸…
• 肽链延长中，转位完成后应出现下列哪一状态？ A、P位是肽酰-tRNA，A位是AA-tRNA B、P位空出，A位是AA-tRN…